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*Correspondence: Zhigang Ren, [email protected] Yu, [email protected] These authors have contributed equally to this work This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

[11] found that NNMT knockdown induced a 47% reduction in the relative fat mass of mice and proposed that NNMT in WATs and/or in livers may have a causative role in obesity

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Eumelanosomes are responsible for producing brown to black pigment, while pheomelanosomes produce red to yellow pigment