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Several direct targets of valproate have been discovered including the mitochondrial enzymes, succinate semialdehyde dehydrogenase and long-chain fatty acid-CoA ligase-4, as well as the family of nuclear-localised histone deacetylases that are involved in epigenetic regulation of gene expression [179,180,181]

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Major physiologic actions associated with native amylin Moreover, Satiation: Amylin contributes to meal termination, helping the nervous system register that enough food has been consumed

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