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B.U.ON, Official Journal Balkan Union Oncol

None of the patients had to discontinue the therapy owing to side effects

KPV is a tripeptide fragment of alpha-MSH that acts on melanocortin receptors to suppress pro-inflammatory cytokines, including TNF-alpha and IL-6

Furthermore, the incidence of metabolic syndrome and type 2 diabetes is higher among patients with bipolar disorder than in the general population and is associated with a worse disease course and poor treatment outcomes [187, 188]

Higher doses (1000mg+) do not proportionally increase plasma glutathione levels due to absorption saturation

We attempted direct inhibition with KMV, but this was toxic to CD8 + T cells at concentrations needed to inhibit the OGDHc, as also observed in HeLa cells