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In the medication off state (12 h after medication withdrawal), five rsfMRI runs (6 min each, totalling 30 min) were acquired with a gradient-echo EPI sequence (TR = 3,000 ms, TE = 30 ms, flip angle = 90, voxel size = 3 3 3 mm 3 , 47 axial slices)

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Start with modest amounts of soluble fibre and increase gradually