Fifty-eight patients with ST-segment-elevation MI and thrombolysis were randomized to receive either saline (n = 40) or exenatide (n = 18, 10 g SC and 10 g as an IV bolus 5 min before the onset of reperfusion plus 10 g SC twice daily on the following 2 days) to evaluate whether this GLP-1R agonist could reduce the area of necrosis
Carbamidomethyl (C) was set as a fixed modification, and acetyl (protein N-term), carbamyl (N-term) and oxidation (M) were set as variable modifications
Semaglutide is occasionally determined by HPLC coupled with spectrophotometric detection
Not recommended for individuals with certain medical conditions or those on specific medications
Our findings are directly consistent with prior reports in advanced CKD and ESRD populations
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