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If A1c is very low, or if the patient is experiencing episodes of hypoglycemia, consider backing off background diabetes therapy, especially if they dont confer CV benefit

Effectiveness of tirzepatide and semaglutide on hunger grows with the dose you are using

Regarding current liver-directed pharmacotherapy, CPGs recommend using pioglitazone and vitamin E in select patient groups with significant fibrosis (F2 fibrosis) by biopsy-proven cases with or without T2DM

doi: 10.1016/s0140-6736(86)90826-3

It can be used independently or integrated into a comprehensive strategy for weight loss or maintenance