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Its potential as an anti-cancer drug is yet to be explored, but results from research so far look promising

Surprisingly, however, in the naked mole-rat, four specific amino acid substitutions in cGAS promote DNA repair and confer a greater capacity to stabilize the genome, counteract cellular senescence and organ aging, and to enhance longevity and health span via evolution (Chen et al., 2025)

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Importantly, at study completion, 5A-1MQ-treated mice had a lower fat mass than the obese WD controls and their vehicle-treated counterparts and were not significantly different (with FDR correction) from the LD control mice (Fig