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It regulates mitochondrial dynamics and protects dopaminergic neurons

10.1146/annurev.pa.25.040185.003435 Ann Rev Pharmacol Toxicol

In 2025, advanced metabolomic studies analyzing the cerebrospinal fluid of ME/CFS patients revealed objective evidence of disrupted one-carbon metabolism in the brain, specifically noting a severe reduction in central nervous system 5-MTHF levels

Huibin Y, Ting A, Yuxuan Z, Xiaojing S, Bangmao W, Qingyu Z

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Key parameters include fasting glucose, HbA1c, liver enzymes (ALT, AST), lipid panel, and body composition metrics