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Presently, 19 different GLP-1 analogues are in development for the treatment of obesity by almost as many companies

Estimated hazard ratio for 6 mg/weekly dose of efpeglenatide compared to placebo was 0,65 (95% CI, 0.5 to 0.86) and 0.82 (95% CI 0.63 1.06) for 4 mg/weekly dose compared to placebo (44)

[19] Pre-existing significant gastrointestinal motility disorders (such as severe gastroparesis) warrant caution with GLP-1 medications

Direct-to-consumer pharmacies like LillyDirect and telehealth platforms like Ro have made self-pay access simpler than it used to be

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Furthermore, exendin-4 has been found to stimulate -cell mass expansion and pancreas regeneration in a partial pancreatectomy rat model of T2DM (129)