Jacobsen SC, Brns C, Bork-Jensen J, Ribel-Madsen R, Yang B, Lara E, Hall E, Calvanese V, Nilsson E, Jrgensen SW, Mandrup S, Ling C, Fernandez AF, Fraga MF, Poulsen P, Vaag A
See these diagrams: Source: Clinical Procedures for Safer Patient Care by Doyle & McCutcheon
The stabilization of HIF-1 under low oxygen levels induces the transcription of glutaminase and GDH, facilitating increased -KG production under metabolic stress
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Zhonghua Xinxueguanbing Zazhi
This can lead to improper titration of the medication, which increases the risk of side effects, reduces effectiveness or may cause dangerous health complications due to unknown ingredients or incorrect dosages