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Major barriers to the clinical use of gene therapy, however, include transfection efficiency, the creation of long-term effects, the difficulty of controlling cell proliferation, ectopic transfection, disease transmission, patient-specific dose responses, immune reactions against viral proteins, possible side effects, and ethical issues [87, 88]
Emodin alleviates joint inflammation and bone erosion in rats with collagen-induced arthritis by inhibiting ferroptosis and degrading matrix metalloproteinases
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The aim of this review was to summarize folic acid, vitamin B12 and homocysteine metabolism in CKD patients and to analyze the published evidences on folic acid and vitamin B12 deficiency as cardiovascular risk markers and therapeutic targets in CKD and ESRD patients
The inclusion criteria were as follows: publications in English, results collected from human studies and in vivo, in vitro experimental studies, systematic review articles, and publications reporting the antiglycoxidant effects of amlodipine
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