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Microtubules regulate adhesion site assembly and turnover during cell migration Focal adhesions are well-characterized sites where integrins engage components of the extracellular matrix to provide traction needed for cell movement and platforms for the assembly and activation of signaling complexes that regulate many aspects of cell behavior including cell migration [66, 67]

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An important role for integrins is to mediate the interaction of cells with ECM components such as fibronectin, and with the intracellular cytoskeleton

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Promote resolution of acute inflammation (shifting from pro-inflammatory to pro-repair signals) while reducing chronic pathological inflammation

Beyond its known side effects, levodopas effectiveness often diminishes as the disease progresses [10]