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Beyond its known side effects, levodopas effectiveness often diminishes as the disease progresses [10]
As such, we generated a mutant D23A at the predicted allosteric site
Regardless of the mechanism, these impairments in ENS signaling could lead to alterations in the gutbrain axis that regulate energy homeostasis, as GF mice are GLP-1 resistant, demonstrating reduced activation of brainstem neurons
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