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Nature Medicine, 28 (10), 2083-2091

& Naqvi, S

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248 Interestingly, in 2008 a study found that the GLP-1 metabolite GLP-1 (936) afforded significant protection against ischemia-reperfusion injury in mice and induced vasodilation in a GLP-1R independent manner

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Its associated with long-term complications including hypertension, stroke, heart failure, and impaired quality of life