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Oxidative Phase: The oxidative phase of the PPP is initiated by the enzyme glucose-6-phosphate dehydrogenase (G6PD)

This natural antioxidant plays a key role in neutralizing harmful free radicals, protecting against oxidative stress[4], and supporting liver function[7]

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Emerging research has found that ferroptosis is involved in these phases and different forms of wound healing

We found that L-GSH supplementation in T2DM subjects modulated levels of IFN-, TNF-, IL-2, and IL-10 within plasma and PBMCs from T2DM subjects

Additionally, mesenchymal progenitor cells acquire a mechanical memory mediated by miR-21, enabling them to maintain a fibrogenic phenotype even after the initial stiffening stimulus has subsided (130)