These include very long term effects beyond ten years, outcomes in younger populations who may use GLP-1s for decades, effects on bone health in older adults, and rare side effects that may only appear with widespread use over time
Limitations include insufficient evidence for all potential harms, subjectivity in harm selection, and reliance on RCT data, which may not fully represent the general population
It's possible that some employers may not put them on their list of covered drugs, said Jeff Levin-Scherz, population health leader at WTW
The tirzepatide syringe injection guide and retatrutide injection guide cover medication-specific technique variations
Final Thoughts GLP-1-based medications have changed the treatment of obesity and type 2 diabetes, and their health benefits can be substantial
Pre-existing heart conditions and hypertensive disorders require extra care