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Low SAM, excessive methylation demand, impaired creatine synthesis, reduced glutathione availability and oxidative stress may place additional strain on mitochondria, potentially contributing to fatigue, variable cognitive stamina, sensory sensitivity, poor stress tolerance and slow recovery from illness

It is a tripeptide composed of the amino acids glutamic acid, cysteine and glycine

Weschawalit, S., Thongthip, S., Phutrakool, P., & Asawanonda, P

Masking was performed to remove alignment ambiguities near gaps

The substrate-binding domain has a three-layer alpha/beta/alpha structure

Bernardini S, Bernassola F, Cortese C, Ballerini S, Melino G, Motti C et al