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Interestingly, the enhanced expression of -adrenergic receptors (ADRBs), namely ADRB2 (2-adrenoreceptor) and ADRB3 (3-adrenoreceptor) has been noted in many cancers, such as breast, colon, gastric, pancreatic, and prostate and has been reported to play a pivotal role in facilitating cancer growth mainly by promoting proliferation, evasion of apoptosis, angiogenesis, invasion and metastasis, and chemoresistance

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Low testosterone levels are particularly common in obese men and those with IR [144, 145]

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