Fluid retention can mask ongoing fat loss on the scales
If these occur, contact your provider immediately for BP assessment and possible medication adjustment to prevent falls or cardiovascular events
However, even small increases in GLP-1 levels achieved by enhanced secretion or slowed degradation can have significant effects on glucose homeostasis, appetite regulation, and gastrointestinal motility
Further understanding the systemic actions of each hormone in isolation or combination with others and their interactions with their respective receptors will likely enable a better understanding of the processes by which humans maintain metabolic homeostasis under healthy conditions and how these are altered during disease, which will then likely yield more effective new therapeutic options for metabolic diseases such as diabetes and obesity
One of the most significant of these is the activation of SIRT1, often called a longevity gene. SIRT1 helps manage insulin sensitivity and supports healthier blood sugar regulation, which is fundamental for sustained energy and preventing the metabolic strain that can lead to weight gain
Presented at 2025 Annual Meeting of the American Academy of Orthopaedic Surgeons
