According to Sikiric et al
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Mohs RC, Davis KL, Tinklenberg JR, Hollister LE
As shown by the decreased expression of Bcl-2/BAX apoptotic genes, APS may also promote apoptosis in activated HSCs in hepatic fibrosis ( 3 Conclusion and Future Perspectives As phytotherapy, APS are appropriate for long-term therapeutic options in patients with chronic illness owing to relatively small toxic side effects, which has been the most difficult issue in the study of NAFLD treatments, resulting in a large number of medicines being abandoned in subsequent clinical trials
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The tradeoff is slightly less precision at the lowest titration doses, though the difference is clinically negligible