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Side Effects The most frequently reported adverse reactions in clinical trials were gastrointestinal disorders, including nausea (very common), diarrhoea (very common) and vomiting (common)

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In addition to the glycemic control, these agents have shown considerable cardiovascular advantages that have been confirmed by large-scale cardiovascular outcome trials (CVOTs) that have shown reductions in major adverse cardiovascular events (MACE), including myocardial infarction (MI), stroke, and cardiovascular death [6,7]

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