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Studies showed that the expression levels of HK2, pyruvate kinase type M2 (PKM2), and Lactate dehydrogenase A (LDHA) in synovial tissues of RA patients were 35 times higher than those of the healthy population

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Administration of semaglutide at the dose regimen of ~ 90 g/kg/day failed to evidence significant weight loss but more importantly, led to alteration of cortical bone microarchitecture, represented by lower cortical thickness, and ultimately to a significant decrease in bone strength [69]

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