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As previously mentioned, the reaction of superoxide radicals with nitric oxide reduces NO bioavailability, leading to impaired endothelium-dependent vasodilation

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Finally, prebiotics, such as 3% galacto-oligosaccharide/fructo-oligosaccharide, have been shown to prevent valproic acid-induced ASD-associated social and cognitive deficits by suppressing microglial activation, lowering Th1 and Th17 and increasing Treg populations, improving intestinal barrier function, and normalizing the gut microbiota composition and SCFA pool [369]