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A steady reduction in astrocytic glutamate transporters, reduced capacity to buffer and disperse K + , and an overall decrease in their ability to sense synaptic activity (partly due to reduced density of ionotropic receptors) was also observed in aged mice (2024-months-old), disrupting long-term potentiation of synapses in the hippocampus (Lalo et al., 2011

Methods We conducted a systematic review of studies from PubMed, Embase, and Cochrane databases (until November 2024), as well as relevant abstracts from Digestive Disease Week (DDW) 2024 and American College of Gastroenterology (ACG) 2024 to assess the impact of GLP-1 receptor agonists (GLP-1 RAs) on EGD

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doi: 10.1172/JCI75276