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Studies on peptide stability show that frozen biologics lose 4070% efficacy even after thawing, depending on freeze-thaw cycle count

Total testosterone decreased by approximately 10%, but changes in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were not significant (32)

The loss of GLP-1 effect on stimulating insulin secretion at basal plasma glucose concentrations limits the hypoglycemic risk even at high pharmacological concentrations of GLP-1 (58)