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This is not a speculative concern it is precisely why parenteral nutrition copper dosing is an order of magnitude lower than oral intake, at 0.30.5 mg/day, and why the dose is reduced, with monitoring of serum concentrations, in cholestasis where biliary excretion is impaired

That is why doctors sometimes prescribe injecting it

Taken together, our observations indicate that HNF4, SAA metabolism genes, and SAA metabolism are positively linked in human liver tumors and cell lines, and that SAA metabolism is altered in HNF4-negative mesenchymal liver cancer cell lines

it does not determine any dose

BSO-induced depletion of GSH in CYP2E1-expressing HepG2 cells causes differential induction of apoptosis and necrosis associated with decreased mitochondrial membrane stability and increased caspase 3 activity [123]

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