Abstract Reactive oxygen species and thiol antioxidants, including glutathione (GSH), regulate innate immunity at various levels
A double-blind, placebo-controlled trial (40 subjects, 28 days) found Cordyceps extract boosted ATP in skin cells by 68%, reduced reactive oxygen species by 30%, increased collagen production by 69% in vitro, and delivered a 28% reduction in wrinkles (PMC11049886)
O 2 are converted to H 2 O 2 and O 2 by mitochondrial or manganese SOD (MnSOD)
USA 107 , 20372042 (2010)
This dual-responsiveness can enhance therapeutic precision, but it also introduces challenges in terms of premature degradation and chemical instability during formulation or circulation
ValiSMythriRBJagathaBPadiadpuJRamanujanKSAndersenJKet alIntegrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinsons disease: a dynamic model