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Further studies will be needed to confirm whether L-carnitine is effective in the clinical setting

302 Notably, microbial metabolites produced by commensal gut flora can limit pathogenic activities of microglia and astrocytes and suppress CNS inflammation in MS experimental models 303 and can contribute to the induction of specific LAMP1+TRAIL+ astrocytes that limit CNS inflammation by inducing T cell apoptosis

The bioavailability of 25(OH)VD 3 in the blood in response to dietary VD intake varies significantly among individual subjects and is dependent on the status of the VD metabolism genes 14,15,16,17

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However, excessive glutamate production can also lead to brain damage and excitotoxicity

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