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After reviewing the research results, the researchers concluded that doses up to 2000 mg per day are safe for long-term use and are an effective dose for most forms of L-carnitine

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In their study, rats exposed to prolonged voluntary alcohol consumption followed by withdrawal exhibited significant upregulation of GRIN2A and GRIN2B (encoding NMDA receptor subunits) in both the hippocampus and prefrontal cortex, along with depression-like behaviors