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Adv Drug Deliv Rev 46(13):89102

Since riboflavin deficiency results in low FMN and FAD contents in the cells, it is plausible that the activities of the flavin-containing enzymes are decreased simultaneously 20

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Recent studies have also shown that a novel anti-proliferation mechanism of MCM2 could be used for potential therapeutic effects in NSCLCs by knockdown of MCM2 inhibiting not only the G1/S cell cycle but also by activation of apoptosis

Systemic Therapy (Severe / Refractory) Methotrexate (weekly oral/injection), cyclosporine for rapid clearance, acitretin for pustular/erythrodermic types

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