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31 The family of PPARs encompasses three subtypes: PPAR-, PPAR-/, and PPAR-

While none currently carry a specific FDA indication for fatty liver disease or NASH, their metabolic effects provide rationale for use in patients with concurrent hepatic steatosis

AOD-9604 has some clinical trial data, though it has not achieved widespread regulatory approval for weight loss

Glucagon-like peptide-1 receptor activation in the nucleus accumbens core suppresses feeding by increasing glutamatergic AMPA/kainate signaling

[12] [13] However, it's important to note that FAERS data cannot establish incidence rates or causality due to voluntary reporting, potential reporting bias, and lack of denominator data

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