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These events stimulate the secretion of insulin, helping to compensate for insulin resistance triggered by new-onset diabetes. The drug also suppresses glucagon release by the pancreas, resulting in glucose-dependent reduction in plasma glucose and postprandial glucose by inhibiting hepatic glucose production and delaying gastric emptying. GLP-1s also act in brain regions associated with appetite and reward, reducing food intake and promoting weight loss

However, it is unsuitable for individuals with a history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

Salt iodization halves risk of thyrotoxicosis in Denmark

A potentially higher occupational risk has been described for several other solid tumors (390)

Consistent sunscreen use is essential during GLP-1 treatment, when facial fat loss may already make fine lines more visible

Substances of Abuse in this section: cocaine and methylenedioxymethamphetamine (MDMA / ecstasy)