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A dose injected into lipohypertrophic tissue may absorb unpredictably, leading to inconsistent blood levels and reduced effectiveness

In the case, the sisters modest weight improvement may benefit from female-specific hormonal environments (e.g., estrogen) that enhance GLP-1 receptor signaling, while the brothers limited response could be related to male-specific factors that blunt semaglutide-induced appetite suppression and energy expenditure regulation

Neumiller, PharmD, CDCES, FADCES, FASCP, can be reached at [email protected]

J Clin Endocrinol Metab (2019) 104:2892902

Hollander, S

The effect of nicotine and dextrose on endoplasmic reticulum stress in human coronary artery endothelial cells Toxicology Research See publication Toxicol Res (Camb)