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L-carnitine plays a pivotal role in energy production within the brain, aiding in mental focus and memory retention

In particular, the aromatization of circulating androgens to estrone in adipose tissue depots amplifies the deregulation of gonadotropin secretion with worsening of hyperandrogenism

5961 These studies have demonstrated that these compounds, in addition to other mechanisms, act by upregulating GPx levels

doi:10.1001/jama.2024.10816

These side effects worsen when you increase the doses of the medication

Preliminary results from the SURPASS-J-mono study in Japanese patients with T2D who were either therapy nave or on an antidiabetic monotherapy showed a head-to-head comparison of a tirzepatide treatment compared to therapy with the GLP-1RA dulaglutide at a dose of 0.75 mg (54, 76)