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Li, Y., Li, J., Dullaart, Robin, P
10.3390/brainsci12060780 127 YangI
firstly, the accumulation of AGEs engages their receptor RAGE on macrophages, initiating robust pro-inflammatory signaling cascades such as the NF-B pathway, which transcriptionally upregulates key M1 markers (e.g., TNF-, IL-6, iNOS) while suppressing M2-associated genes like Arg1 (Dong et al., 2016
We go on to show that rewiring 2-OG metabolism through ABHD11 inhibition yields distinct outcomes, depending on the cell type
PMID: 2272034
Reported benefits (per available research): Studied for its ability to raise GH and IGF-1 toward youthful levels and blunt age-related loss of fat-free mass, based on a 2-year randomized, placebo-controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine, PMID 18981485)
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