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Usual target dose: 300 mg per day (150 mg twice daily)

This adjustment period is exactly why doctors do not start patients on the highest dose right away

Most of the patients were malnourished as a result of multiple medical comorbidities, and most had some degree of kidney dysfunction or overt failure

doi: 10.1097/00004836-200603000-00015 265 XiaoY.HuangL.ZhaoJ.ChenW.LuW

25: 14853 Bartel LL, Hussey JL, Shrago E

Distinguishing between appropriate frequency from increased fluid intake and pathological frequency from bladder inflammation requires paying attention to accompanying symptoms, particularly burning, urgency, and changes in urine appearance or smell