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456 In the spinal cord, the influx of neuropathic signals to the dorsal horn leads to central sensitization, characterized by increased spontaneous neuronal activity, lowered activation thresholds for peripheral stimuli, heightened responses to sub-threshold stimuli, and expansion of receptive fields

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Finally, benzhexol may induce agitation, insomnia, delirium, anxiety, and visual hallucinations (83)

Glutamine and glutamate are also the nitrogen donors for many key metabolic pathways