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It also has a huge impact on the endocrine system which manifests itself as malfunctioning endocrine glands and leads to endocrine disorders ( via the hormonal system and the nervous system via indirect pathways

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Specific Adjustments and Administration Details: Renal and Hepatic Insufficiency: A highly unique and beneficial feature of linagliptin compared to other drugs in the DPP-4 Inhibitor class is that no dose adjustment is required for patients with kidney (renal) or liver (hepatic) impairment

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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Tu Y., Sun W., Wan Y.-G., Che X.-Y., Pu H.-P., Yin X.-J., Chen H.-L., Meng X.-J., Huang Y.-R., Shi X.-M