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For instance, alcohol-mediated inactivation of mitochondrial enzymes such as ALDH2 [53] and its isozymes [57], involved in cellular defense against toxic acetaldehyde, acrolein, MDAL, and other reactive carbonyl compounds, may increase sensitivity toward tissue damage by MDMA or vice versa [44, 96101]

Genomic instability in mice lacking histone H2AX

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The antipsychotic spiperone attenuates inflammatory response in cultured microglia via the reduction of proinflammatory cytokine expression and nitric oxide production

Therefore, we cant exclude the possibility that other pathways may contribute to ferroptosis inhibitory effect of cholesterol