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You take certain medications: Long-term use of proton pump inhibitors (for acid reflux) or metformin (for diabetes) can interfere with B12 absorption

The speed at which you experience a pick-me-up after a B12 injection can vary depending on a few factors: The Severity of Your Deficiency If you have a mild deficiency, you might feel a difference in energy levels within a few days to a week

This breaks the peptide structure

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B12 injections can begin working within hours or a few days