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[184] reported that Piper nigrum fruit extract increased Th1 cytokines and suppressed Th2 and Th17 cytokines in AR mice, which may be related to the inhibition of the STAT3 and NFB pathways

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They found that high-dose IGF-1 was beneficial to cartilage formation, while low-dose IGF-1 was more conducive to subchondral bone reconstruction [35]

& Martins, L