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Separate acute from chronic, and put a boundary on duration If someone is intent on using it, the least risky scenario is short-term use around a clearly defined acute injury window, not ongoing use for months for chronic pain

These include: Molecular interactions between receptors Cell signalling pathways Pharmacokinetics Metabolism Human clinical trials under strict control Biomarker reactions Site-specific effects The developments in the field of peptide chemistry might lead to enhanced molecular stability, selectivity for receptors, and analytical techniques

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