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335,361 The delivery efficiency is mainly dependent on the lipid membrane and the active proteins which mediate the internalization between exosomes and target cells

10.1212/wnl.42.7.1328 190 SharpC

Both trials implemented similar inclusion and exclusion criteria and had similar baseline populations

* indicates that the study scores in this domain of Jadad

GLP-1 is rapidly degraded by DPP-4 enzyme in the body, showing the shorter half life

Individual speakers at a 2024 National Academies workshop suggested that GLP-1R agonists may reach the brain mainly through specialised uptake at the circumventricular organs, regions that sit outside the standard barrier, rather than by penetrating it