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[36] [17] Phase 2 data showed dose-dependent weight loss in adults with obesity or overweight without diabetes, and phase 3 ATTAIN studies support clinically meaningful weight reduction in adults with and without type 2 diabetes

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Although preclinical studies have illustrated that pure nanotherapeutics possess some therapeutic functions, challenges still remain in their low accumulation at the targeted areas and easy leakage, which may cause therapeutic inefficiency to hinder subsequent clinical translation 23,24,25