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Thus,the respectable control levels of plasma vitamin C reported in India - at Madras (36), Delhi (10), and Cochin (62) - are misleading if the Madras results can be generalized

Chilton, Didcot, Oxfordshire: Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC (2018)

Herce, H

Overall, existing studies suggest that microbial metabolites may act as multifunctional neuroprotective modulators, influencing metabolic, epigenetic, immunological, and barrier-stabilizing processes, with potential relevance for modifying neurodegenerative disease progression [148]

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Both sit at the preclinical tier mechanistically plausible, supported by cell-culture and animal studies, but not confirmed by controlled human trials