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Part 1 of 2 covers the mechanism and the U/kg trend, the portal-peripheral mismatch, and the Ominous Octet framework

The result is methyl B12, which is then used to re-methylate homocysteine, converting it to methionine, then to SAMe

71 : 54 - 58 Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A

The study's authors were careful to note that these findings are early and specific to their study population

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Patients with pre-existing diabetic retinopathy should be monitored closely, as rapid improvement in blood glucose control may temporarily worsen retinopathy