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In cosmetics, HJE works mainly to soften skin, reinforce the barrier, and lock in moisture by reducing water loss

Grucza RA, Bierut LJ

Regulation of other signaling pathways In addition to Nrf2 and insulin signaling pathways, lipoic acid was found to target other cell-signaling molecules thereby affecting a variety of cellular processes, including metabolism, stress responses, proliferation, and survival

Nelson DB, Rice DC, Niu J, Atay SM, Vaporciyan AA, Antonoff MB, Hofstetter WL, Walsh GL, Swisher SG , Roth JA, Tsao AS, Gomez DR, Giordano SH, Mehran RJ, Sepesi B

75 Conversely, forced overexpression of CDO1 in breast cancer cells shifted the flux from glutathione synthesis towards cysteine catabolism, consequently increasing ROS levels and leading to reduced cell viability and growth

Glutathione is more effective for pigmentation and brightening, while collagen targets firmness and wrinkles