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Their findings suggested that the increase in HR may centrally depend on activation of the autonomic nervous system, while cardiac GLP-1R is not essential

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Of note, the level of certainty in this recommendation is higher for the former subgroup, because some CVOTs recruited exclusively people with established CVD, while fewer events were recorded for participants with cardiovascular risk factors only in CVOTs that recruited both subgroup populations

After all, GLP-1 drugs are approved to be used as a supplement to, rather than a replacement for, healthy lifestyle changes

Additionally, their impact on weight loss is a highly beneficial side effect, especially given the close relationship between obesity and type 2 diabetes