36,37 In two of the aforementioned trials, researchers reported changes in each of the 11 symptoms on the MRS: women taking the Siberian rhubarb extract in these trials experienced significant reductions in all 11 items on the MRS after 12 weeks compared with those taking placebo.35,36 In a follow-up study, 80 of the initial 109 participants were given the same dose of the extract for 48 weeks of observation, and 51 continued treatment for an additional 48 weeks
The 7% body weight reduction observed in mouse models may not translate proportionally to human weight loss it could be more, less, or require entirely different dosing and duration
That dual action is why the results tend to be more significant
PMCID: PMC11013451 Paryab N, Taheri M, HMida C et al (2021) Melatonin supplementation improves psychomotor and physical performance in collegiate student-athletes following a sleep deprivation night
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