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Front Endocrinol (Lausanne) 14:1237882

Similarly, in patients with hypertension and hyperhomocysteinemia (18 males and 7 females, age 4065), reactive hyperemia is improved by 4 weeks oral L-arginine (Reule et al., 2017), administered in a mixture with pycnogenol, which itself activates eNOS (Fitzpatrick et al., 1998)

Some long-term users cycle three months at maintenance concentration followed by one month at elevated concentration for periodic intensive phases